The forward’s debut season with the Parthenopeans has been hampered by injury, suspension and coronavirus-related problems.
The Nigeria international only recently returned from a shoulder injury and was handed his seventh league start against the Goddess.
With few minutes left before the end of the game, Osimhen collided with Romero and was immediately taken out on a stretcher.
The center-forward was then rushed to the hospital by an ambulance, where he would be expected to continue his treatment.
The Super Eagles forward has only played 16 games across all competitions for Napoli, scoring two goals and providing one assist since his €80 million move from Lille last summer.
It is yet to be known the extent of Osimhen’s injury and the duration he would be on the sidelines for as he would be expected to undergo tests.
Osimhen injury could be a big blow for Nigeria national team coach Gernot Rohr, who is set to name the forward in his team for the 2022 Africa Cup of Nations qualifiers in March.